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September 2016

Volume 2 Issue 9

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Case Report

Surgical Skin Tumors in Neurofibromatosis 1 (NF1) at the Dakar Cancer Institute

Sidy KA*, Carine Bagré, Maimouna Mané, Doudou Diouf, Ahmadou Dem

Neurofibromatosis type 1 (NF1) or Von Recklinghausen disease is a genetic condition with autosomal dominant transmission. Signs of Von Recklinghausen's disease are many and skin tumors represent an important part. The majority of these tumors are benign, but what make the severity of NF1 is the large tumors or royal tumors and the high frequency of malignant nerve sheath tumors.                                            

                                                                                                                                                                     Download PDF Full text

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Review article

Immunological Checkpoints: CD137 and LAG3 Receptors as a Target for Cancer Immunotherapy - Literature Review

Michał Palonka*, Paulina Nazaruk, Anna Wilk1, Paweł Krawczyk, Janusz Milanowski

In recent years, the search for more efficient and less toxic anti-cancer therapies focuses on monoclonal antibodies targeting cells’ immune checkpoints. Stimulation of the immunological response against tumor cells is potentially safer than chemotherapy. However, the currently used anti-PD1, anti-PD-L1 or anti-CTLA4 antibodies are effective in a limited population of patients and also immunotherapy may induce autoimmune toxicity. The aim of this study was to present the latest information on anti-CD137 and anti-LAG3 monoclonal antibodies in anticancer therapy.                                            

                                                                                                                                                                     Download PDF Full text

 

 

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