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 March 2016

 Volume 2  Issue 3                             

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Review article
Immunotherapeutic Approach to Anal Cancer

Timothy Allen, MD, Ph.D., Ghazaleh Shoja E Razavi* MD

Anal cancer is a rare disease that accounts for 0.4% of all cancer diagnoses in the United States. Its incidence has increased by 2.2% annually. The risk factors associated with anal cancer are Human Papilloma Virus (HPV), Human Immunodeficiency Virus (HIV), sexual practices, smoking and immunosupression. Immunotherapy is an alternative to chemotherapy and radiation that uses a patient’s own immune system to fight the cancer. This can be done by giving the patients man-made immune system proteins to stimulate their immune system. In this paper, we will discuss the current trends in utilizing immunotherapy to fight anal cancer along with the different molecules involved in the proliferation of the disease.
                                              

                                                                                                                                                                     Download PDF Full text

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Review article
Therapeutic approach to CML in TKI era

Timothy Allen, MD, Ph.D., Ghazaleh Shoja E Razavi* MD

Chronic myeloid leukemia is a cancer that affects the cells of the bone marrow. These effected cells can grow and divide rapidly and spill into other parts of the body. It is relatively prevalent in the United States with 14% of cancer diagnoses being for CML. Immunotherapy is a new way to fight this cancer. The new era in the management of CML has started with the advent Tyrosine kinase inhibitors. This therapy stimulates one’s own immune system to fight the malignant tumor. We can classify the immunotherapeutics into TKI therapies and non TKI therapies broadly. In this paper, we discussed the causes, epidemiology, and potential immunotherapeutic techniques to treat CML.
                                              

                                                                                                                                                                    Download PDF Full text

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Review article
Immunotherapy and Cervical Cancer

Timothy Allen* MD, Ph.D , Giridhar M.N.V, MD, MBA, Ghazaleh Shoja E Razavi MD

Cervical cancer is a leading cause of death worldwide, as per statistical analysis, it is the seventh most common cancer. Majority of the cervical cancers are caused by persistent infections with specific types of the human papillomavirus (HPV). HPV-infected cells produce specific proteins, or antigens that can be recognized by T cells, which are immune cells that play a critical role in the body’s response to infectious agents and infected cells. As there are specific targets for development of cervical cancer immunotherapy is emerging as promising treatment for cervical cancer
                                              

                                                                                                                                                                     Download PDF Full text

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Review article
HIV and HTLV1 Associated Lymphoma and Immunotherapy

Timothy Allen* MD, Ph.D , Giridhar M.N.V, MD, MBA, Ghazaleh Shoja E Razavi MD

People with HIV infections are at increased risk for lymphoma. It is a disease in which malignant cells form in the lymphatic system of patients who have acquired immunodeficiency syndrome. The use of highly active anti-retroviral therapy (HAART) to treat HIV has helped patients to better tolerate treatments such as chemo and immunotherapy. Targeted immunotherapies are the evolving therapies where drugs that block the growth and spread of the cancer by interfering with specific molecules that are involved in carcinogenesis.
                                              

                                                                                                                                                                     Download PDF Full text

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